PRP vs. PRF | Refined Dermatology, Los Gatos + San Jose


Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections have a lot of similarities, but there are also some big differences between the two. At Refined Dermatology, we’ll work with you to discuss the benefits of each and provide you with a customized recommendation. PRP has been around a little longer, and it’s more recognizable than PRF—but that doesn’t mean it should be overlooked. PRF might just give you the results you really deserve.

How PRP works

PRP works by drawing a vial of the client’s blood, spinning it in a centrifuge to separate the platelets and growth factors, then injecting these powerful elements directly into the targeted site. PRP can be used esthetically to encourage new collagen growth to help with skin issues and even promote hair growth. The PRF process begins in much the same way, but PRP is spun at a higher rate so that the heavier cells (like stem cells and white blood cells) gather at the bottom of the tube. This is what lets the platelets and plasma to move to the top.

The PRF difference

However, some studies suggest that a platelet sample that has some levels of stem cells and white blood cells can be an effective form of treatment. PRF is spun at a slower speed so that there’s some amount of these elements in the final product. The separation of the elements isn’t quite as distinct. According to some supporters, this means you get even more healing factors with PRF compared to PRP. Plus, a lower spin rate means less trauma to every cell.

There’s also a difference between the concentration of platelets with PRP vs. PRF. Many researchers suggest that the ideal platelet concentration is between 2 – 5 times the amount normally found in the body. However, recent research shows that perhaps 10 times the amount is best. PRP offers between 2 – 5 times the normal amount while PRF offers 10 times the amount.

Schedule your consultation with Refined Dermatology today

Finally, there’s no anticoagulant in PRF while there is with PRP. No anticoagulant means the fibrinogen in the blood turns into fibrin as soon as clot formation begins. This fibrin acts like a sponge while it slowly releases the growth factors. There’s no one clear winner between PRP and PRF, and many clients try out both to see which they prefer. To schedule a consultation or appointment for either procedure, contact Refined Dermatology today.